These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Pharmacokinetic study of ofloxacin using saliva concentration in chronic renal failure].
    Author: Tsubakihara Y, Hayashi T, Shoji T, Kitamura E, Okada N, Nakanishi I.
    Journal: Nihon Jinzo Gakkai Shi; 1994 Mar; 36(3):246-9. PubMed ID: 8196221.
    Abstract:
    We evaluated saliva concentration as a parameter of therapeutic drug monitoring (TDM) of Ofloxacin (OFLX) in patients with severe renal failure (CRF). Saliva OFLX concentration correlated closely with serum OFLX concentration as shown in healthy subjects, although it was significantly lower (about three-quarters), indicating that OFLX had less penetration into saliva in patients with renal failure. Saliva concentration was almost equal to serum concentration during hemodialysis, which might have been due to the constant dialysis of OFLX. In conclusion, saliva concentration was useful for TDM of OFLX in patients with CRF, as it is in healthy subjects.
    [Abstract] [Full Text] [Related] [New Search]