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  • Title: Neuroendocrine ampullary tumors: spectrum of disease including the first report of a neuroendocrine carcinoma of non-small cell type.
    Author: Emory RE, Emory TS, Goellner JR, Grant CS, Nagorney DM.
    Journal: Surgery; 1994 Jun; 115(6):762-6. PubMed ID: 8197570.
    Abstract:
    Primary neuroendocrine tumors of the ampulla of Vater are rare. These tumors, like those of the respiratory tract and remainder of the gastrointestinal tract, appear along a histologic spectrum of increasing malignancy from low-grade carcinoid tumors to high-grade small cell undifferentiated cancers. We herein describe the characteristics of these ampullary neoplasms and report the first case of a neuroendocrine carcinoma of non-small cell type, which represents the middle of this histologic continuum. This tumor seems to follow a more aggressive course than the carcinoid tumor but less aggressive than its small cell counterpart.
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