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  • Title: [The genesis of experimental granulosa cell tumors of the ovaries].
    Author: Vol'fson NI.
    Journal: Vopr Onkol; 1976; 22(3):68-75. PubMed ID: 820073.
    Abstract:
    Ovaries and their tumors were investigated in virgin female mice (78 control and 252 experimental) of line A and CC57W (aged-from 1 to 1 1/2 months) in the experiments with intravaginal application of polyurethan, 7,12-dimethylbenz (a) anthracene, 8-oxychinoline, synoestrol. It was demonstrated that only granulosa elements of atresic follicles are involved in the process of blastomogenesis. Theca-tissue showed no appreciable participation in proliferative processes. Totally, pretumor changes were noted in 56 cases, folliculomas or pathological changes morphologically identical to microfolliculomas- in 26 cases.
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