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  • Title: Diagnostic value of anti-neutrophil cytoplasmic and anti-endothelial cell antibodies in early Kawasaki disease.
    Author: Guzman J, Fung M, Petty RE.
    Journal: J Pediatr; 1994 Jun; 124(6):917-20. PubMed ID: 8201476.
    Abstract:
    OBJECTIVE: To assess the diagnostic potential of anti-neutrophil cytoplasmic antibodies (ANCA) and anti-endothelial cell antibodies (AECA) to distinguish early Kawasaki disease (KD) from febrile diseases resembling KD. DESIGN: Case-control study. SETTING: Tertiary care facility. PATIENTS: Eighteen patients with KD tested within 2 weeks of disease onset and before immune globulin therapy; 20 control children with fever and at least one other KD criterion; 21 children with noninflammatory disorders (patients scheduled for elective surgery, or after trauma). METHODS: We detected ANCA by immunofluorescence and enzyme-linked immunosorbent assay (ELISA), and AECA by a cell-ELISA with fixed human umbilical vein endothelial cells. RESULTS: We found that 7 of 18 patients with KD and 6 of 20 febrile control patients had ANCA (by immunofluorescence or ELISA, p value not significant); 3 of 18 patients with KD and 8 of 20 febrile control patients had AECA (p value not significant). One of three patients with KD who had aneurysms had ANCA; none had AECA. CONCLUSIONS: The ANCA and AECA tests used in this study did not differentiate early KD from other childhood diseases with which it may be confused.
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