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  • Title: Activity of amphotericin B, 5-fluorocytosine, and rifampin against six clinical isolates of Aspergillus.
    Author: Kitahara M, Seth VK, Medoff G, Kobayashi GS.
    Journal: Antimicrob Agents Chemother; 1976 Jun; 9(6):915-9. PubMed ID: 820247.
    Abstract:
    Amphotericin B in combination with 5-fluorocytosine was synergistic against three clinical isolates of Aspergillus fumigatus and one of three clinical isolates of A. flavus. Amphotericin B in combination with rifampin was synergistic against all six clinical isolates of Aspergillus tested. The levels of 5-fluorocytosine and rifampin required for synergism were higher than clinically achievable concentrations when measurements of synergism were based on visual turbidity; but when the effects of the drugs were measured by inhibition of ribonucleic acid synthesis or dry-weight increase, much lower concentrations were effective.
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