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  • Title: Strial dysfunction in a melanocyte deficient mutant rat (Ws/Ws rat).
    Author: Kitamura K, Sakagami M, Umemoto M, Takeda N, Doi K, Kasugai T, Kitamura Y.
    Journal: Acta Otolaryngol; 1994 Mar; 114(2):177-81. PubMed ID: 8203200.
    Abstract:
    A homozygous mutant rat at the white spotting (Ws) locus showing a deficiency of melanocytes has recently been found (4, 5). The function and morphology of the inner ear of the Ws/Ws rat were examined by auditory brainstem response (ABR), endocochlear DC potential (EP), and electron microscopy. The mean ABR threshold of the Ws/Ws rat was significantly higher than that of the control +/+ rat. Most Ws/Ws rats showed no or very little EP. In electron microscopy, the stria vascularis of the Ws/Ws rat proved to be very thin and flat with poor interdigitation of marginal cells, and absence of intermediate cells. The organ of Corti appeared to be intact in both the +/+ rat and the Ws/Ws rat. These electrophysiological and morphological findings suggest that the Ws/Ws rat suffered from severe hearing loss caused by strial dysfunction.
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