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  • Title: Selective inactivation of vitamin B12 in rats by nitrous oxide.
    Author: Deacon R, Lumb M, Perry J, Chanarin I, Minty B, Halsey MJ, Nunn JF.
    Journal: Lancet; 1978 Nov 11; 2(8098):1023-4. PubMed ID: 82036.
    Abstract:
    Exposure of rats to nitrous oxide rapidly inactivated the cytosol enzyme, methionine synthetase, but the mitochondrial enzyme, methylmalonyl CoA mutase, seemed to be unaffected, although both enzymes require vitamin B12.
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