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  • Title: Glycerol phosphorylcholine (GPC) and serine ethanolamine phosphodiester (SEP): evolutionary mirrored metabolites and their potential metabolic roles.
    Author: Burt CT, Ribolow H.
    Journal: Comp Biochem Physiol Biochem Mol Biol; 1994 May; 108(1):11-20. PubMed ID: 8205386.
    Abstract:
    Water-soluble phosphodiesters (WSPDE) are a prominent feature of many 31P-NMR spectra; however, their role has remained somewhat of a mystery. What has been missed in almost all previous studies is the fact that two classes of WSPDE exist in vertebrates: those in mammals and those in the other (reptile-avian) line. The first is represented by glycerol phosphorylcholine and the second by serine ethanolamine phosphodiester. A further examination of the literature suggests a common role for all WSPDE as lysophospholipase inhibitors and therefore net sparers of phospholipids by decreasing phospholipid metabolic throughput.
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