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  • Title: QX-314 blocks the potassium but not the sodium-dependent component of the opiate response in locus coeruleus neurons.
    Author: Alreja M, Aghajanian GK.
    Journal: Brain Res; 1994 Mar 14; 639(2):320-4. PubMed ID: 8205485.
    Abstract:
    Opiates hyperpolarize locus coeruleus neurons by simultaneously opening K+ channels and turning off a resting Na(+)-dependent inward current. Intracellularly applied QX-314 reduced the opiate current to approximately 40% of the control and the residual current did not reverse near EK, suggesting lack of a significant K+ component. Replacement of Na+ virtually abolished the residual opiate response. Thus, QX-314 blocks the K+ but not the Na(+)-dependent component of the opiate-induced outward current in LC neurons.
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