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  • Title: Prostaglandin H synthase: implications for membrane structure.
    Author: Picot D, Garavito RM.
    Journal: FEBS Lett; 1994 Jun 06; 346(1):21-5. PubMed ID: 8206152.
    Abstract:
    The crystal structure of the membrane protein prostaglandin H synthase (PGHS) provides strong evidence for the existence of monotopic membrane proteins: PGHS seems to interact with the membrane via a motif of amphipathic helices positioned parallel to the plane of the membrane. The orientation of this unique membrane binding motif is fixed in space by an epidermal growth factor(EGF)-like module on its amino-terminal end and by the catalytic domain at its carboxy-terminal end. The catalytic domain of PGHS has a high structural homology to other mammalian heme peroxidases.
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