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  • Title: Manganese toxicity: muscarinic receptor binding in the mouse brain.
    Author: Villalobos V, Castro F, Bonilla E, Estévez J, Dávila JO.
    Journal: J Toxicol Environ Health; 1994 Jun; 42(2):185-91. PubMed ID: 8207754.
    Abstract:
    In the present study we determined the effect of repeated administration of manganese chloride on the binding parameters of [3H]quinuclidinyl benzilate (3H-QNB) in striatum, frontal cortex, and hippocampus of mice. Daily intraperitoneal injections of manganese chloride (5 mg Mn/kg) 5 d/wk during 9 wk did not alter the receptor density (Bmax) and the dissociation constant (Kd) of 3H-QNB in the different brain regions studied. These results suggest that chronic treatment with manganese does not affect the binding characteristics of 3H-QNB to the cholinergic muscarinic receptors in mouse brain.
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