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  • Title: Serotonergic function in panic disorder: endocrine responses to D-fenfluramine.
    Author: Judd FK, Apostolopoulos M, Burrows GD, Norman TR.
    Journal: Prog Neuropsychopharmacol Biol Psychiatry; 1994 Mar; 18(2):329-37. PubMed ID: 8208982.
    Abstract:
    1. Prolactin and cortisol responses to d-fenfluramine were measured in 16 patients with DSM-III-R panic disorder and 14 normal controls. 2. Patients showed a greater mean prolactin response than controls but the difference between groups was not statistically significant (P > 0.05, MANOVA). 3. No consistent differences were observed between patients and controls with respect to cortisol responses (P > 0.05, MANOVA). 4. The results do not support the hypothesis of hypersensitive post-synaptic serotonin receptors in patients with panic disorder. 5. Studies in larger groups are necessary to confirm the trend and to explore receptor subtype sensitivity.
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