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  • Title: [Morphological pictures of renal biopsy specimens in glomerulopathies related to rheumatoid arthritis (RA)].
    Author: Danilewicz M, Wagrowska-Danilewicz M.
    Journal: Przegl Lek; 1994; 51(1):5-8. PubMed ID: 8208996.
    Abstract:
    The authors reevaluated 21 renal biopsy specimens from patients with rheumatoid arthritis (RA) and clinical symptoms of glomerulopathy. The patients were divided into three groups: in the I group they were treated with nonsteroid antiinflammatory drugs, in the II one with gold and in the III group with D-penicillamine. Pathomorphological study based on light microscopy, immunohistochemistry and electron microscopy showed that forms of primary renal involvement (group I) and secondary renal involvement (group II and III) in patients with rheumatoid arthritis were very similar to the types of glomerulonephritis not related to RA. The authors pointed out, that in the most cases immunohistochemistry revealed immunoglobulins (IgG,IgA,IgM,C3) and electron microscopy investigations showed deposits in various parts of the glomeruli. This observations support opinions, that immune complex mechanism takes a great role in pathogenesis of glomerulopathy in RA.
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