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  • Title: Mutation induction by different dose rates of gamma rays in near-diploid mouse cells in plateau- and log-phase culture.
    Author: Furuno-Fukushi I, Aoki K, Matsudaira H.
    Journal: Radiat Res; 1993 Oct; 136(1):97-102. PubMed ID: 8210344.
    Abstract:
    Induction of mutation to 6-thioguanine resistance was studied in cultured near-diploid mouse cells (m5S) in plateau and log phase after exposure to gamma rays at dose rates of 30 Gy/h, 180 mGy/h, or 13 mGy/h. In plateau-phase culture, lowering the dose rate from 30 Gy/h to 13 mGy/h resulted in an increase in cell survival and a marked decrease in induced mutation frequency. On the other hand, in the log-phase culture, the magnitude of the dose-rate effects was not as marked as in the plateau-phase culture, particularly within a dose range below 5 Gy. These results, together with those indicating the inverse dose-rate effects in growing mouse leukemia cells (Radiat Res. 115, 273-280, 1988), demonstrate the significant influence of cell growth that takes place during protracted irradiation, particularly for the induction of mutation.
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