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  • Title: Tachykinin receptors in the rat isolated uterus.
    Author: Fisher L, Pennefather JN, Hall S.
    Journal: Regul Pept; 1993 Jul 02; 46(1-2):396-8. PubMed ID: 8210502.
    Abstract:
    Tachykinin receptors mediating uterotonic effects were examined in preparations from oestrogen-primed rats. In the absence of peptidase inhibitors [Lys5-MeLeu9-Nle10] NKA (4-10) was 14-fold more potent than neurokinin A (NKA), but the two peptides were equipotent in the presence of phosphoramidon alone and in combination with amastatin. The NK-2 receptor antagonist SR 48968 antagonised responses to the tachykinins. These findings indicate that an NK-2 receptor is present in the oestrogen-primed rat uterus and that endopeptidase 24.11 plays a major role to inactivate NKA in this tissue.
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