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  • Title: Cessation of long-term naltrexone therapy and self-injury: a case study.
    Author: Crews WD, Bonaventura S, Rowe FB, Bonsie D.
    Journal: Res Dev Disabil; 1993; 14(4):331-40. PubMed ID: 8210609.
    Abstract:
    The cessation of long-term Naltrexone administration was investigated through a double-blind, placebo-controlled, withdrawal design in a 28-year-old, profoundly mentally retarded woman with a history of severe self-injurious behavior (SIB). The subject had previously exhibited a dramatic decrease in SIB subsequent to Naltrexone administration. At the end of 1 year of continuous drug treatment, the subject displayed a near-zero rate of SIB episodes. This near-zero rate continued through placebo and no-drug phases of the study and at 6-month (no-drug) follow-up. This trend suggests not only that Naltrexone may be effective in reducing SIB, but that long-term administration may produce durable results after treatment cessation. Findings are discussed in relation to the endogenous opioid system theories of SIB.
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