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  • Title: [Platelet function after allogeneic bone marrow transplantation in Wiskott-Aldrich syndrome].
    Author: Megido M, Cesar JM, Maldonado MS, Otheo E, Muñoz A, Navarro JL.
    Journal: Sangre (Barc); 1993 Jun; 38(3):233-4. PubMed ID: 8211550.
    Abstract:
    PURPOSE: To assess the platelet characteristics and functionalism in the Wiskott-Aldrich syndrome (WAS) after allogeneic BMT using cyclophosphamide and busulphan for conditioning. MATERIAL AND METHODS: Two WAS patients underwent allogeneic BMT. Platelet aggregation was studied prior to and after BMT, along with the intraplatelet amount of ADP and ATP. RESULTS: Platelet count, size and aggregation wholly recovered after BMT. The post-transplant content of platelet nucleotides was normal. CONCLUSIONS: Platelet function can be totally restored with cyclophosphamide/busulphan conditioned BMT in WAS. Platelet defects in this disease are due to defective thrombopoiesis.
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