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  • Title: Alpha/beta value and importance of dose per fraction for the late rectal and recto-sigmoid complications.
    Author: Deore SM, Shrivastava SK, Supe SJ, Viswanathan PS, Dinshaw KA.
    Journal: Strahlenther Onkol; 1993 Sep; 169(9):521-6. PubMed ID: 8211671.
    Abstract:
    A total of 203 patients with cancer of cervix stage IIIB, treated by radiation alone were analysed retrospectively for the incidence of late rectal and recto-sigmoid complications. The patients were treated with a combination of external irradiation and a single intracavitary insertion during January 1979 to December 1983. The external irradiation was randomised to deliver by four different fractionation regimens having dose per fraction of 2 Gy, 3 Gy, 4 Gy and 5.4 Gy. The doses for various fractionation regimens were matched using the time dose factors (TDF) model. 39 cases of late radiation induced rectal and recto-sigmoid complications were observed. The complication rate increased significantly (p < 0.05) with the size of dose per fraction. Using this clinical data an alpha/beta value of 3.87 +/- 0.74 Gy was estimated for late rectal and recto-sigmoid complications.
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