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  • Title: [The effect of hydroxymethyl derivatives of 7,12-dimethylbenz(a)anthracene on its metabolism and toxic action in tissue culture].
    Author: Belitskiĭ GA, Lopp AKh, Khesina AIa.
    Journal: Tsitologiia; 1975 Dec; 17(12):1415-20. PubMed ID: 821192.
    Abstract:
    The naturally occurring hydroxymethyl derivatives of the carcinogen 7,12-dimethylbenz(a)anthracene was found to inhibit the metabolic hydroxylation and toxic effect of this carcinogen in mouse embryo fibroblast-like cell culture. The greatest reduction of both effects was obtained when 12-hydroxymethyl-7-methylbenz(a)anthracene was added to the growth medium, less effective were, resp., 7,12-dihydroxymethylbenz(a)-anthracene and 7-hydroxymethyl-12-methylbenz(a)anthracene. The data obtained are discussed in terms of the intracellular regulation of carcinogenic hydrocarbon metabolism.
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