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  • Title: [Comparison of the effects of molsidomine retard and isosorbide dinitrate retard in patients with stable angina pectoris using an ergometry test].
    Author: Rotrekl P, Vlasínová J, Manousek J, Semrád B, Rysavý F, Lupínek Z, Meluzín J, Vlasicová I, Pirochtová I, Bocek O.
    Journal: Vnitr Lek; 1993 Sep; 39(9):856-64. PubMed ID: 8212639.
    Abstract:
    In 24 men with angina after exertion the authors assessed, using ergometry, the action of molsidomine retard and isosorbide dinitrate retard after a single dose and after tree-week administration of the drug. The authors found that 8 mg of molsidomine retard in a single dose had a somewhat more potent effect than 40 mg isosorbide dinitrate retard. After prolonged administration the effect of both drugs on haemodynamics diminished and in molsidomine a significant decline of action was observed before development of a reduced S-T segment on the ECG. After three weeks' administration the effects of both drugs were comparable. After neither drug clinically significant tolerance developed when the drug was administered every 8 hours. In the conclusion the authors discuss possible mechanisms involved in development of tolerance.
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