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  • Title: Oral vaccination of racoons (Procyon lotor) with baculovirus-expressed rabies virus glycoprotein.
    Author: Fu ZF, Rupprecht CE, Dietzschold B, Saikumar P, Niu HS, Babka I, Wunner WH, Koprowski H.
    Journal: Vaccine; 1993; 11(9):925-8. PubMed ID: 8212838.
    Abstract:
    Successful field oral vaccination and protection against viral diseases have so far been achieved only with live-attenuated or live-recombinant virus vaccines. In this communication, we present data that demonstrate that a glycoprotein derived from recombinant baculovirus-infected insect cells is efficacious as an oral vaccine. The glycoprotein (G) of rabies virus (Evelyn Rokitnicki Abelseth strain) was abundantly expressed in a baculovirus expression system and oral vaccination of racoons with the baculovirus-expressed G protein resulted in the production of rabies virus-neutralizing antibodies and protection against a lethal challenge with a street rabies virus. The potential for using the baculovirus-expressed G protein for oral immunization of wildlife is discussed.
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