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  • Title: [Highperformance liquid chromatographic assay for lomefloxacin in plasma and its pharmacokinetics in healthy volunteers].
    Author: Tan L, Xu DK, Diao Y, Yuan YS.
    Journal: Yao Xue Xue Bao; 1993; 28(4):286-9. PubMed ID: 8213172.
    Abstract:
    A sensitive and simplified high performance liquid chromatographic procedure has been developed for quantification of lomefloxacin in human plasma. The recovery of lomefloxacin was 95 to 102%. The relative standard deviation was 2.1 to 7.8%. The calibration curve was linear in the range from 0.125 micrograms/ml to 5.012 micrograms/ml with r = 0.9998. The detection limit of the method is 25 ng/ml. The plasma drug concentration-time course after medication conformed to a 1-compartment open model with a first order absorption. Mean t1/2 value was 5.5 h.
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