These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: In vitro postantibiotic effect following repeated exposure to imipenem, temafloxacin, and tobramycin.
    Author: McGrath BJ, Marchbanks CR, Gilbert D, Dudley MN.
    Journal: Antimicrob Agents Chemother; 1993 Aug; 37(8):1723-5. PubMed ID: 8215293.
    Abstract:
    The postantibiotic effect (PAE) following three consecutive 2-h exposures to imipenem, temafloxacin, and tobramycin was determined in Pseudomonas aeruginosa. A PAE and a bactericidal effect were consistently observed for imipenem following each cycle of drug exposure and regrowth. In contrast, the PAE increased with repeated exposure with temafloxacin (1.8 to > 5 h), but disappeared with tobramycin by the third exposure (0.9 to 0 h). These data show that the in vitro PAE may change within a strain following multiple cycles of drug exposure and bacterial regrowth.
    [Abstract] [Full Text] [Related] [New Search]