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  • Title: Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD.
    Author: Hollander E, Cohen LJ, DeCaria C, Saoud JB, Stein DJ, Cooper TB, Islam NN, Liebowitz MR, Klein DF.
    Journal: Biol Psychiatry; 1993 Sep 15; 34(6):407-13. PubMed ID: 8218609.
    Abstract:
    The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role in cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.
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