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  • Title: Thalamic low threshold calcium current in a genetic model of absence epilepsy.
    Author: Guyon A, Vergnes M, Leresche N.
    Journal: Neuroreport; 1993 Sep 10; 4(11):1231-4. PubMed ID: 8219019.
    Abstract:
    The low threshold calcium current (IT) in thalamo-cortical neurones contributes to the generation of spike and wave discharges (SWDs) characteristic of generalized, non-convulsive absence epilepsy. The biophysical properties of this current were analysed in dorsal lateral geniculate neurones from the Genetic Absence Epilepsy Rats from Strasbourg (GAERS+). No difference was found in the voltage dependence and kinetics of IT between GAERS+ and rats of the non epileptic control strain (GAERS-). Thus, a dysfunction of IT does not appear to underlie the occurrence of SWDs in absence epilepsy.
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