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  • Title: [The behavioral and neurochemical changes in rats caused by the subchronic administration of haloperidol].
    Author: Shevchenko TP, Tolpyshev BA, Zban' LN.
    Journal: Eksp Klin Farmakol; 1993; 56(3):15-7. PubMed ID: 8219980.
    Abstract:
    Rat experiments showed that subchronic haloperidol enhanced or perverted motor asymmetry appearing in response to apomorphine, resulted in imbalance between the dopaminergic and serotoninergic systems and increased norepinephrine levels. It was concluded that intra- and interhemispheric imbalance might be one of the causes of extrapyramidal disorders associated with the long-term administration of the neuroleptic.
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