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  • Title: [The characteristics of the effect of imperialone on the M-cholinoreceptors of different organs].
    Author: Mirzaev IuR, Plotnikova IT, Shakirov R.
    Journal: Eksp Klin Farmakol; 1993; 56(4):14-7. PubMed ID: 8220005.
    Abstract:
    The pharmacological studies of the steroidal alkaloid imperialone have revealed its high M-cholinolytic activity on the heart, which was accompanied by sensibilization of M-cholinoreceptors in the secretory cells of lacrimal, salivary, and gastric glands and M-receptors in the smooth muscle of the intestine and urinary bladder. Bearing in mind the currently available data on M-cholinoreceptors, imperialone can be regarded as M2-cholinolytics having M3- and M4-cholinopotentiating properties. Imperialone is a potent agent used for selective cardiac M2-receptor blockade and for enhancement of the functional activity of smooth muscle and secretory organs that have M3- or M4-cholinoreceptors.
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