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  • Title: [Experimental and clinical studies of the action of verapamil (finoptin) on the cerebral circulation in transient cerebral ischemia].
    Author: Miller LG, Zakharova MA, Burtsev EM, Savkov VS.
    Journal: Eksp Klin Farmakol; 1993; 56(4):19-22. PubMed ID: 8220007.
    Abstract:
    The experiments on unanesthetized rats have established that the intravenous injection of verapamil in a dose of 0.6 mg/kg during 30-minute carotid occlusion with subsequent recirculation prevents postischemic hypoperfusion, normalized oxidative processes and prevents brain tissue edema. In patients with transient cerebral circulatory disorders, a single injection of verapamil in a dose of 10 mg enhances the pulse filling of cerebral vessels. During a course therapy, the drug decreases minor and middle vessel tone, increases the REG amplitude, lowers the interhemispheric asymmetric blood filling rate, and enhances the functional resistance of cerebral vessels.
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