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  • Title: Partial trisomy 1q, an uncommon chromosomal aberration in erythroleukemia.
    Author: Baumgarten E, Wegner RD, Fengler R, Koch H, Henze G.
    Journal: Leuk Lymphoma; 1993 Jun; 10(3):237-40. PubMed ID: 8220123.
    Abstract:
    A 2 years 4 months old boy with erythroleukemia (FAB-M6) and Down's syndrome is described. Chromosome analysis of bone marrow leukemic blasts revealed apart from the trisomy 21 a partial trisomy of the long arm of chromosome 1:1q23-->1qter in all cells and trisomy 8 mosaicism. To the best of our knowledge this is the first time that a partial trisomy of chromosome 1 in association with erythroleukemia has been described. Previous reports of other hematologic malignancies with aberrations of chromosome 1 indicate that the breakpoint 1q23 is nonrandom and that trisomies of chromosome 1 plays a crucial role in the course of development of hematologic malignancies. This could probably also be true for erythroleukemias.
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