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  • Title: Altered levels of histone H1(0) and DNA topoisomerase activity in the liver of the tumour-bearing rat.
    Author: Goodlad GA, Clark CM.
    Journal: Biochem Mol Biol Int; 1993 Aug; 30(6):1043-52. PubMed ID: 8220251.
    Abstract:
    Walker 256 carcinoma cells were injected subcutaneously into the dorsal region of rats. After 9 days of tumour growth increases were observed in liver mass and DNA content and in the incorporation of [3H]-thymidine into liver DNA. These changes were accompanied by a fall in the H1(0) fraction of liver histones and rises in both DNA topoisomerase I and II activities.
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