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  • Title: Autoradiographic analysis of (14C-methyl)-L-methionine uptake in transplanted rat brain tumors.
    Author: Sasajima T, Mineura K, Kuwahara N, Kowada M, Murakami M, Uemura K.
    Journal: Noshuyo Byori; 1993; 10(1):7-9. PubMed ID: 8220785.
    Abstract:
    To elucidate metabolic pathways of methionine in brain tumors, we studied autoradiographic images of (14C-methyl)-L-methionine (14C-Met) in transplanted rat brain tumors. 14C-Met accumulated in the tumor almost twice as much as in the gray matter 90 min after injection. The acid-insoluble fraction, which was bound to macromolecules, comprised 84% the total count of the accumulated tracers in the tumor. Analysis of 14C-Met tracer accumulation is informative for understanding amino acid metabolism in brain tumors.
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