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  • Title: Myocardial and circulatory performance during the ischemic phase of superior mesenteric artery occlusion.
    Author: Jamieson WG, DeRose G, Harris KA, Pliagus G, Stafford L.
    Journal: Can J Surg; 1993 Oct; 36(5):435-9. PubMed ID: 8221400.
    Abstract:
    OBJECTIVE: To investigate myocardial and circulatory parameters during the acute ischemic phase of mesenteric artery occlusion. DESIGN: A prospective, randomized, control trial. SUBJECTS: Twelve, adult, mongrel dogs. INTERVENTIONS: In seven dogs the superior mesenteric artery was occluded with two silk ligatures (experimental group). In five dogs the ligatures were not tied (control group). Measurements were made during 7 hours of occlusion. MAIN OUTCOME MEASURES: Myocardial performance and circulatory performance. RESULTS: There were significant (p < 0.05) reductions in arterial blood pressure, mean pulmonary artery pressure, diastolic pulmonary artery pressure and cardiac index in dogs exposed to intestinal ischemia compared with the control dogs. No differences were identified in ventricular performance, stroke volume index or peripheral vascular resistance index. CONCLUSIONS: Early cardiac and central circulatory changes in massive intestinal ischemia are due to intravascular hypovolemia. Sepsis and myocardial depressant factors were not found to be a cause of death.
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