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  • Title: Transcatheter occlusion of the patent ductus arteriosus in the presence of mild isthmal hypoplasia.
    Author: Nykanen DG, Hayes AM, Benson LN, Freedom RM.
    Journal: Cathet Cardiovasc Diagn; 1993 Aug; 29(4):273-6. PubMed ID: 8221845.
    Abstract:
    Between January 1990 and February 1992, 5 asymptomatic patients were identified with hypoplasia of the aortic isthmus at the time of cardiac catheterization for closure of a small patent ductus arteriosus. Isthmal diameters measured from lateral aortograms were 62 +/- 11% of age-matched controls. All patients had a small communication occluded with a 12 mm device and remained asymptomatic at 6-30 months follow up. Residual shunting was demonstrated by color Doppler in 2 patients. No child has developed an arm-leg systolic blood pressure gradient or systemic hypertension. Following device placement, Doppler interrogation across the isthmus in 2 patients demonstrated a velocity shift of 2.1 m/s. Transcatheter occlusion of the patient ductus arteriosus associated with mild isthmal hypoplasia of the aortic arch appears safe and effective and does not result in a clinically significant impairment to isthmal flow in short-term follow-up.
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