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  • Title: Levo-praziquantel versus praziquantel in experimental and clinical treatment of schistosomiasis japonica.
    Author: Liu YH, Qian MX, Wang XG, Quan YZ, Yan SH, Chen BY, Li JS, Qiu ZY.
    Journal: Chin Med J (Engl); 1993 Aug; 106(8):593-6. PubMed ID: 8222907.
    Abstract:
    Levo-praziquantel is the left isomer of racemic praziquantel. Animal experiments showed that it is an active component of schistosomicidal activity, while dextro-praziquantel is almost ineffective. Clinical trials in three endemic areas of Schistosomiasis japonica indicated that the therapeutic efficacy of levo-praziquantel is superior to racemic praziquantel. Pharmacokinetic and pharmacodynamic activities of the stereoselectivity of praziquantel isomers (enantiomers) are discussed.
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