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  • Title: Effect of levamisole on the synthesis of macromolecules in log phase and synchronized cultures of Tetrahymena pyriformis, GL.
    Author: Pan HY, Hokama Y, Chou SC.
    Journal: Res Commun Chem Pathol Pharmacol; 1976 Aug; 14(4):651-7. PubMed ID: 822485.
    Abstract:
    The effects of levamisole on log phase and synchronized cultures of Tetrahymena pyriformis, strain GL, have been examined. At a dose of 100 mug/ml, DNA, RNA and protein syntheses were inhibited by 38%, 27% and 19%, respectively, in log phase cells, and by 21%, 50% and 47%, respectively, in synchronized cells. Lipid synthesis was only slightly inhibited (15%) at this same dose in synchronized cells. Results suggest that levamisole may act by directly inhibiting nucleic acid syntheses and the inhibition of protein synthesis may be secondary to this effect.
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