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  • Title: Synthesis and antifungal activity of pradimicin derivatives. Modifications on the aglycone part.
    Author: Aburaki S, Okuyama S, Hoshi H, Kamachi H, Nishio M, Hasegawa T, Masuyoshi S, Iimura S, Konishi M, Oki T.
    Journal: J Antibiot (Tokyo); 1993 Sep; 46(9):1447-57. PubMed ID: 8226323.
    Abstract:
    Synthesis and antifungal activity of pradimicin analogs modified on the aglycone part is described. Upon modification studies at various sites of the aglycone part using pradimicin A (PRM A), C-11 position was found to be the sole site to be modified without loosing antifungal activity. Further modification studies at C-11 position were carried out with 11-OH derivative of pradimicin T1 (PRM T1) because of its easy availability. Among the compounds prepared, 11-demethoxy derivative of PRM A (12) and 11-O-ethyl (13) and 11-O-fluoroethyl (14) derivatives of PRM T1 showed promising antifungal activity comparable to that of PRM A.
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