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  • Title: [Glutathione reductase deficiency with membrane defect in hereditary hemolytic anemia].
    Author: Pohl A, Bugajer-Gleitman HE, Lachmann D, Moser K.
    Journal: Acta Haematol; 1976; 56(1):47-57. PubMed ID: 822675.
    Abstract:
    Glutathione reductase activity and phospholipid metabolism in red cell membranes were determined in a family with hereditary hemolytic anemia. A marked decrease of glutathione reductase activity and stability of reduced glutathione was found in combination with enhanced phospholipid-phosphate metabolism and decreased activity of the membrane-stabilizing enzyme lysolecithin-acyltransferase. In all cases splenectomy beneficially influenced the hemolytic process. Family studies revealed a dominant-autosomal genetic transmission.
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