These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of prophylactic ampicillin on pelvic infection following vaginal hysterectomy.
    Author: Glover MW, van Nagell JR.
    Journal: Am J Obstet Gynecol; 1976 Oct 01; 126(3):385-8. PubMed ID: 822722.
    Abstract:
    One hundred patients undergoing vaginal hysterectomy at the University of Kentucky Medical Center were given prophylactic ampicillin and compared to one hundred control patients. The use of prophylactic ampicillin caused significant reduction in both postoperative pelvic infection and hospital stay. However, two patients in the prophylactic antibiotic group later required readmission for infections resistant to ampicillin. Prophylactic antibiotics are beneficial in vaginal hysterectomy, but careful follow-up of all patients is mandatory. From 1971 to 1975 a study was conducted to determine the effect of prophylactic ampicillin on febrile morbidity and hospital stay following vaginal hysterectomy. Of 300 patients, 100 received .5 gm ampicillin orally at 12 and 6 hours prior to surgery, .5 gm iv at surgery, and every 6 hours thereafter for 4 doses; 100 patients received prophylactic penicillin and streptomycin; and 100 received no antibiotics. Febrile morbidity was reduced (p less than .001) in the ampicillin group, the incidence of pelvic infection declining from 18% to 3%. (Results on the penicillin group are published elsewhere.) However, 2 patients required readmission for pelvic infection due to ampicillin-resistant organisms. It is concluded that prophylactic antibiotics are beneficial in vaginal hysterectomy but that careful follow-up is needed because of the possibility of delayed infection.
    [Abstract] [Full Text] [Related] [New Search]