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  • Title: Validation of a metabolic prototype to assist in the treatment of insulin-dependent diabetes mellitus.
    Author: Lehmann ED, Deutsch T, Roudsari AV, Carson ER, Sonksen PH.
    Journal: Med Inform (Lond); 1993; 18(2):83-101. PubMed ID: 8231426.
    Abstract:
    This paper describes the principles and prototyping of a computer system to assist in the treatment of patients with insulin-dependent (type 1) diabetes mellitus. The system adopts a mixed approach involving rule-based qualitative algebra and a dynamic mathematical model to define the relationships between insulin dosage, diet and glycaemic response. The rule-based system (KBS), implemented in PROLOG, can be used to generate qualitative therapeutic advice. These suggestions are quantified and rank-ordered by the use of a mathematical model of glucose-insulin interaction in type 1 diabetes mellitus, with parameters adjusted for individual patients. In this paper an overview of the integrated prototype, linking the KBS and model, is provided and a case study used to demonstrate the principles of the system in operation. The results of verification and validation work performed on the KBS are described.
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