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  • Title: Inhibition of monoamine oxidase-A of rat brain by pyrethroids--an in vitro kinetic study.
    Author: Rao GV, Rao KS.
    Journal: Mol Cell Biochem; 1993 Jul 21; 124(2):107-14. PubMed ID: 8232282.
    Abstract:
    An in vitro kinetic study on inhibition of the monoamine oxidase-A (MAO-A) of the rat brain by two pyrethroids, namely permethrin (PM) and cypermethrin (CPM), has shown that PM and CPM competitively inhibit MAO-A by altering both the Michaelis-Menten constant (Km) and the maximum velocity (Vmax). Inhibitor constant values (Ki) indicated that CPM was a more effective inhibitor of MAO-A than PM. Both PM and CPM caused maximum inhibition of MAO-A at neutral pH. CPM significantly elevated the activation energy values of MAO-A as compared to those of PM.
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