These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Interstitial radiosurgery of low grade glioma].
    Author: Kreth FW, Warnke PC, Ostertag CB.
    Journal: Nervenarzt; 1993 Oct; 64(10):633-9. PubMed ID: 8232676.
    Abstract:
    In this retrospective study the outcome of 324 patients with low-grade gliomas (WHO-Grade II) is evaluated, who from 1979 to 1991 underwent stereotactic biopsy and interstitial radiosurgery (Iodine-125). The patients were selected for interstitial radiosurgery if the tumor was unifocal, well-circumscribed and in diameter < or = 4 cm. Of these patients 251 had astrocytomas, 29 had oligodendrogliomas, and 44 had oligoastrocytomas. All patients presented with progressive neurological deficit or showed evidence of CT/MRI confirmed tumor growth. The preoperative performance status was > or = 70%. Diffusely infiltrative, non-delineated gliomas and gliomas crossing the midline were excluded. Five-year survival rates were 65% for astrocytomas, 80% for oligoastrocytomas and 58% for oligodendrogliomas. In the multivariate analysis age was a significant factor predicting survival. Patients who received temporary implants had a significantly better outcome than those with permanent implants. Radiation toxicity (3.1%) was seen mostly among the permanent implants. No patients required reoperation due to radionecrosis. The findings in this subgroup of gliomas indicate that interstitial radiosurgery using Iodine-125 is effective in controlling tumor growth and is well tolerated. Patients with differentiated and circumscribed gliomas particularly benefit from the treatment.
    [Abstract] [Full Text] [Related] [New Search]