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  • Title: [The circadian rhythm of ciliary beat frequency of human nasal cilia in probands with healthy lungs and in patients with chronic obstructive lung disease. Includes adrenergic stimulation by terbutaline].
    Author: Thomas A, Petro W, Konietzko N.
    Journal: Pneumologie; 1993 Sep; 47(9):526-30. PubMed ID: 8234224.
    Abstract:
    Brush biopsies taken from the human nose eight times during 24 hours were examined under a phase contrast microscope and the ciliary beat frequency was measured directly by a photosensitive cell. Ten healthy volunteers showed in two series of measurements, at 600, 1200, 1800, 2400 initially and 300, 900, 1500, 2100 six weeks later, a marked decrease in ciliary beat frequency towards the middle of the day and a statistically higher beat frequency in the early morning. The influence of the adrenergic drug terbutaline led to a cilioexcitation ranging from 0.1-1.4 Hz (mean: 0.9 Hz). In contrast to, neither a circadian variation of the ciliary beat frequency nor a stimulation by terbutaline could be observed in a group of fifteen patients with chronic bronchitis or bronchiectasis at 600, 1200, 1800 and 2400.
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