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  • Title: Anti-sperm antibodies and semen profiles in re-anastomosed men.
    Author: Kay DJ, Clifton V, Taylor JS, Boettcher B.
    Journal: Reprod Fertil Dev; 1993; 5(1):135-9. PubMed ID: 8234889.
    Abstract:
    A group of 29 re-anastomosed men were examined with respect to semen quality, anti-sperm antibody titres in serum and seminal plasma, presence of anti-sperm antibodies on sperm, and success rate in inducing pregnancy. Results indicated no association between pre-reversal serum anti-sperm antibody titres and post-reversal semen quality, but a pregnancy induction rate of zero was associated with serum anti-sperm antibody titres greater than 160. It is recommended that men considering reversal, with anti-sperm antibody titres of this level, should receive counselling about the possibility of post-reversal infertility. In Newcastle, New South Wales, Australia, health workers obtained sera and semen samples from 29 men requesting a vasectomy reversal to examine anti-sperm antibody profiles and their pregnancy induction rate after reanastomosis. The researchers also wanted to determine some preoperative parameters that predict postoperative success. The antisperm antibody titres of 329% of the men were clinically significant (gelatin agglutinin test titres 1/40). Among the men who wanted to have children 42% were able to induce pregnancy. About 47% of men with no antisperm antibodies were able to induce pregnancy. No man with antisperm antibody titres of at least 160 were able to induce pregnancy. The exact probability of pregnancy occurring by chance in these men was just 0.14%, which was statistically significant. No association between prereversal serum antisperm antibody titres and postreversal semen quality existed. These findings led the researchers to recommend that any man with a serum antisperm antibody titre of at least 160 who wants to undergo vasectomy reversal should be about the low probability of postreversal infertility.
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