These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Low response of DNA synthesis upon growth stimulation in LEC mutant rat.
    Author: Kim JK, Yamada T, Sogawa K, Agui T, Matsumoto K.
    Journal: Res Commun Chem Pathol Pharmacol; 1993 Sep; 81(3):369-72. PubMed ID: 8235070.
    Abstract:
    Long-Evans Cinnamon (LEC) mutant rat, which spontaneously develops a chronically necrotizing hepatic injury at 4 months of age, exhibits an excess hepatic copper accumulation. DNA synthesis upon growth stimulation in LEC rat primary-cultured hepatocytes markedly decreased when compared to that of normal rat hepatocyte culture. Low response of DNA synthesis seems to be associated with nuclear disorganization induced by copper toxicity. However, LEC rat electrophoretic profile and content of each histone component responsible for DNA stability were indistinguishable from those of normal rat. These results suggest that copper-generated damage of substrates other than histones causes nuclear damage in LEC rat.
    [Abstract] [Full Text] [Related] [New Search]