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  • Title: Solvent exposure, alcohol consumption and liver injury in workers manufacturing paint.
    Author: Rees D, Soderlund N, Cronje R, Song E, Kielkowski D, Myers J.
    Journal: Scand J Work Environ Health; 1993 Aug; 19(4):236-44. PubMed ID: 8235512.
    Abstract:
    Liver enzyme activity was examined in 89 South African paint makers currently exposed to a mixture of organic solvents at fairly low levels. However, the duration of exposure was substantial for many. Fifty-eight workers (65%) had at least one enzyme value above the upper reference limit. Gamma glutamyl transferase (gamma GT) activity was elevated in 46% of the workers and aspartate aminotransferase (ASAT) in 52%. In a comparison between workers with high and low solvent exposure, the gamma GT and ASAT values were higher in the most exposed group (eg, gamma GT mean 108 versus 69 U.l-1, P > 0.05). Adjustment for confounding by alcohol consumption and body mass index eliminated the differences due to exposure. It was concluded that the measures of liver injury used did not demonstrate solvent-induced hepatic damage but that excessive alcohol consumption was an important factor.
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