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  • Title: [Immunoglobulin decrease accompanying adverse reactions with bucillamine].
    Author: Inokuma S, Sakata M, Ando J, Kobayashi S, Kiyosawa H, Nozawa F, Ito K.
    Journal: Ryumachi; 1993 Aug; 33(4):316-24. PubMed ID: 8235913.
    Abstract:
    Forty-two RA patients treated with Bucillamine (B) were divided into two groups with (n = 26) and without (n = 16) adverse reactions, and IgG, M, A and total protein concentration x globulin ratio (Ig) before and after B were compared. IgG did not differ before B administration, but was significantly lower in the adverse reactions group after B, and in each group it was significantly lower after B treatment with a much greater decrease demonstrated in the adverse reactions group. IgA before B did not differ either between the two groups or between before and after B administration in the non-adverse reaction group, but was significantly lower only after B in the adverse reaction group. IgM did not differ either before or after B treatment between the two groups, and was significantly lower following B administration in both groups. Ig showed results similar to IgA. In the adverse reaction group, IgG, A, M and Ig recovered following suspension of administration. It is concluded that the adverse reaction brought on by B administration might occur with the decrease in immunoglobulin.
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