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  • Title: [Effectiveness and safety of 150 mg vs 300 mg ranitidine twice a day in duodenal ulcer].
    Author: Schraier M, Jorge A, Pereyra JC, Carri J, Padua-Videla M, Hoffenberg P, Villalobos J, Orillac J, Waserstein M, Mendoza S.
    Journal: Acta Gastroenterol Latinoam; 1993; 23(1):13-7. PubMed ID: 8237259.
    Abstract:
    394 patients with endoscopically diagnosed duodenal ulcer were randomly allocated to treatment with ranitidine 150 bid o ranitidine 300 mg bid in a prospective double-blind multicenter trial conducted in seven LatinoAmerican countries. Endoscopy at 4 weeks showed complete ulcer healing en 171 of 196 patients (87.2%) treated with ranitidine 150 mg bid and 178 of 198 (89.9%) treated with ranitidine 300 mg bid. Both treatment regimens were equally effective at rapidly reducing the incidence of ulcer-related symptoms. It is possible that higher dosage regimen of ranitidine would be useful in patients with more severe duodenal ulcer disease.
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