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  • Title: Evaluation of liver function and lipid metabolism following Norplant-2 rods removal.
    Author: Singh K, Viegas OA, Loke DF, Ratnam SS.
    Journal: Adv Contracept; 1993 Sep; 9(3):233-9. PubMed ID: 8237578.
    Abstract:
    The effect of Norplant-2 rods on liver function and lipid metabolism was evaluated in 100 Singaporean women. As with the Norplant six-capsule, the only change noted in liver function was that of a significantly elevated bilirubin, which was within the normal clinical range for the local population. As regards lipid metabolism, the mean values for total triglycerides, cholesterol, LDL-cholesterol and HDL-cholesterol seen at the end of five years of Norplant-2 rod use and six months postremoval were similar to the preinsertion mean. As a result, the HDL-cholesterol/total-cholesterol-HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratio remained fairly constant. This indicates that the use of Norplant-2 rods does not directly contribute to cardiovascular risk.
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