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  • Title: Comparison of intubation following propofol and alfentanil with intubation following thiopentone and suxamethonium.
    Author: Beck GN, Masterson GR, Richards J, Bunting P.
    Journal: Anaesthesia; 1993 Oct; 48(10):876-80. PubMed ID: 8238830.
    Abstract:
    We have compared a rapid sequence induction of anaesthesia using propofol 2 mg.kg-1 and alfentanil 50 micrograms.kg-1, with a standard technique using thiopentone 5 mg.kg-1 and suxamethonium 1 mg.kg-1. The incidence of complications, and the quality of conditions for intubation, were similar in both groups. The patients receiving propofol and alfentanil showed a significant decrease in blood pressure and heart rate following induction (p < 0.01), whereas the group receiving thiopentone and suxamethonium showed a significant increase in blood pressure and heart rate following induction (p < 0.01). The use of propofol and alfentanil provided a satisfactory alternative to thiopentone and suxamethonium for a rapid sequence induction of anaesthesia.
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