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  • Title: [Changes in the content of microelements--copper, zinc and iron--in the blood of patients following cardiopulmonary bypass].
    Author: Dementéva II, Andrianova MIu, Dzemeshkevich SL, Iavorovskiĭ AG, Lokshin LS.
    Journal: Anesteziol Reanimatol; 1993; (4):50-3. PubMed ID: 8239030.
    Abstract:
    Changes in the blood content of trace elements (E)--copper, zinc and iron--have been studied in 10 patients with ischemic heart disease subjected to cardiopulmonary bypass surgery. It has been shown that blood TE concentrations decreased considerably during surgery. Variability in blood TE levels could be accounted for by hemodilution caused by the administration of colloids and crystalloids that contained no TE under study. These solutions were used initially for filling assisted circulation device. However, it is noteworthy that the degree of hemodilution was not the only reason for the changes in blood TE content, as despite hematocrit normalization it was only blood iron content that returned to preperfusion level. It has been demonstrated that copper and zinc blood concentrations were considerably lower in patients developing heart failure in the early postperfusion period than in those with an uncomplicated postoperative period. It has been shown that the nature and degree of changes in copper, zinc and iron levels in the coronary sinus blood during heart surgery can be assessed by changes in their arterial blood content.
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